Expression of a single major histocompatibility complex locus controls the immune complex locus controls the immune response to poly-L-(tyrosine, glutamic acid)-poly-DL-alanine--poly-L-lysine
نویسندگان
چکیده
منابع مشابه
Expression of a single major histocompatibility complex locus controls the immune complex locus controls the immune response to poly-L-(tyrosine, glutamic acid)-poly-DL-alanine—poly-L-lysine
Genetic control of the immune response linked to the major histocompatibility (H-2) complex in the mouse has been described for synthetic polypeptide antigens and for low doses of native proteins. The phenomenon is well documented(1,2). Extensive screening of intra-H-2 crossover-derived recombinant strains has localized H-2-linked immune response (Ir) genes to the I-immune response region of th...
متن کاملLinkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs.
The data presented demonstrate linkage between the major histocompatibility locus of inbred strain 2 guinea pigs and a "specific immune response gene," the PLL gene, which controls responsiveness to poly-L-lysine and hapten conjugates of this polypeptide in these animals. This finding extends to another species and to a different immune system the linkage observed in mice between the H(2) locus...
متن کاملShell and core cross-linked poly(L-lysine)/poly(acrylic acid) complex micelles.
We report the versatility of polyion complex (PIC) micelles for the preparation of shell and core cross-linked (SCL and CCL) micelles with their surface properties determined by the constituent polymer composition and cross-linking agent. The negatively and positively charged PIC micelles with their molecular structure and properties depending on the mixing weight percentage and polymer molecul...
متن کاملThe effect of aliphatic alcohols on the helix-coil transition of poly-L-ornithine and poly-L-glutamic acid.
The helical stability of poly-L-glutamic acid and poly-Lornithine in aqueous alcohol solutions was studied by optical rotatory dispersion and potentiometric titration determinations. It was found that aliphatic alcohols enhance the stability of the helix according to the series methanol < ethanol < I-propanol < I-butanol. The role of secondary and tertiary alcohols was also investigated. Thermo...
متن کاملThioflavin T forms a non-fluorescent complex with α-helical poly-L-glutamic acid.
Thioflavin T (ThT) is a molecular-rotor-type fluorophore reputed for the selective binding to amyloid fibrils. Using induced circular dichroism, here we show that ThT binds in an orderly manner to α-helical poly-L-glutamic acid (PLGA) implying that neither stacked β-sheets nor π-π stacking interactions are necessary for the binding between the dye and proteins.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1978
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.147.2.599